Structure of Elastin in the Dermis

Structure of Elastin in the Dermis

The dermis is vital for the body’s skin health. It contains several components, including proteins such as elastin. Elastin plays an essential role in the structure and function of skin tissue, providing elasticity and resilience to the epidermis. In this blog post, we will discuss the structure of elastin in more detail.

Elastin is a protein composed of amino acids that are linked together in a specific sequence. It has a unique structure that allows it to stretch and recoil back to its original shape when stretched or compressed. This special property enables it to provide strength and flexibility to tissues, allowing them to move and bend without breaking. With aging and environmental factors like sun damage, our elastin fibers degrade. This loss of elasticity is a contributing factor in skin appearing looser and saggy.

The primary components of elastin are two amino acid cross-links known as desmosine and isodesmosine (D/I). These amino acids are arranged into an alpha helix structure with four sections that form a repeating pattern known as tropoelastin monomers. The tropoelasmin monomers then form long strands that wrap around each other like coils, forming larger structures known as microfibrils. These microfibrils are arranged in bundles and held together by cross-links formed by D/I molecules. These bundles give elastin its unique elastic properties, allowing it to stretch up to 1.5 times its original length before returning to its original shape.

In addition to D/I molecules, elastin also contains small amounts of other proteins such as lysyl oxidase (LOX) which helps stabilize the structure of elastin by cross-linking different sections together. Elastin also contains glycosaminoglycans (GAGs), which help attract water molecules needed for hydration and cell growth within the dermis layer.

Elastin is an important component of skin tissue due to its ability to provide strength while still being flexible enough for movement and stretching without breaking down easily or becoming damaged permanently over time. Its unique structure provides both strength and flexibility while helping maintain skin health through hydration and cell growth within the dermis layer. Understanding how elastin works can help us better understand how our skin works on a cellular level, and the important role it plays in the appearance of our skin.
Back to blog